PROTAC SMARCA2/4-degrader-20 [CAS 2568277-38-1]

PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-20 degrades SMARCA2 in A549 and MV411 with DC50 SMARCA4 in MV411 with DC50 of 100-500 nM. (Pink: Ligand for Target Protein ; Black: Linker (HY-W006635) ; Blue: Ligand for E3 Ligase (HY-163932) )

[2568277-38-1]

C50H58F3N11O6S

998.13

NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=C(C=C(C9=C(N=CS9)C)C=C8)OC(F)(F)F)=O)=O)=O)C=N5)C(CC4)C3

Epigenetic Reader Domain; PROTACs

Room temperature