PROTAC SMARCA2/4-degrader-25

PROTAC SMARCA2/4-degrader-25 (compound 7d) is a PROTAC targeting SMARCA2/4. PROTAC SMARCA2/4-degrader-25 is composed of E3 ligase (2S,4R) -4-Hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide (blue part), PROTAC Linker (S) -2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and target protein ligand SMARCA2/4-ligand-3 (HY-162814) (red part). The conjugate of E3 ubiquitin ligase ligand + Linker is (S, R, S) -AHPC (HY-125845).

C44H50N10O9S2

927.06

O=S(C1=CC=C([N+]([O-])=O)C=C1)(OC2=CC=CC=C2C3=NN=C(N)C(N4CCN(CC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)CC4)=C3)=O

Epigenetic Reader Domain; PROTACs

Room temperature