PROTAC SMARCA2/4-degrader-30 [CAS 2568276-44-6]

PROTAC SMARCA2/4-degrader-30 (Compound I-291) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-30 degrades SMARCA2 in A549 and in MV411 with DC50 SMARCA4 in MV411 with DC50 [1].

[2568276-44-6]

C44H51N11O4

797.95

OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC=C(C6CCN([C@H]7CC[C@H](C8=CC(N(C)C(N9C%10CCC(NC%10=O)=O)=O)=C9C=C8)CC7)CC6)C=N5)C3)=C(N)N=N2

Epigenetic Reader Domain; PROTACs

Room temperature