PROTAC SMARCA2/4 degrader-38 [CAS 3081688-77-6]

PROTAC SMARCA2/4 degrader-38 is a degrader SMARCA2/4 PROTAC (DC50: 3.0 nM and 4.0 nM respectively). PROTAC SMARCA2/4 degrader-38 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-38 blocks the G0/G1 cell cycle and induces apoptosis. PROTAC SMARCA2/4 degrader-38 can be used in acute myeloid leukemia (AML) research. (Pink: SMARCA2/4 ligand; Blue: VHL ligand ; Black: linker; Target Protein Ligand-Linker Conjugates (HY-173343) ).

[3081688-77-6]

C43H47N7O5S

773.94

O=C([C@H]1N(C([C@@H](NC(C2(C3=CC=C(C4=CC(C5=CC=CC=C5O)=NN=C4N)C=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C

Apoptosis; Epigenetic Reader Domain; PROTACs

Von Hippel-Lindau (VHL)

99.46

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature