PROTAC SMARCA2/4 degrader-40

BRM/BRG1 ligand 4 (Compound 6) is a SMARCA2/4 PROTAC degrader. BRM/BRG1 ligand 4 exhibits potent degradation activity against both SMARCA2 and SMARCA4 in HeLa cells, with DC50 less than 0.1 nM. BRM/BRG1 ligand 4 can be used for the study of cancers associated with SMARCA2/SMARCA4 abnormalities or SWI/SNF mutations[1].

C41H45N9O5

743.85

CC[C@@](N1C2)(CNC3=C1C=C(C4=C(O)C=CC=C4)N=N3)C[C@H]2OC(N=C5)=C(C)C=C5CN(CC6)CCN6C7=CC(C8=O)=C(C=C7)CN8[C@H](C(N9)=O)CCC9=O

PROTACs

Room temperature