PROTAC SMARCA2/4-degrader-9 [CAS 2568507-15-1]

PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2 in MV411 and in A549 with DC50 SMARCA4 in MV411 with DC50. (Pink: Ligand for target protein ; Black: Linker (HY-W006635) ; Blue: Ligand for E3 ligase (S, R, S) -AHPC (HY-125845) )

[2568507-15-1]

C49H59N11O5S

914.13

NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6CCC(CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)C=N5)C(CC4)C3

Epigenetic Reader Domain; PROTACs

Room temperature