PROTAC SMARCA2 degrader-35 [CAS 3032998-97-0]

PROTAC SMARCA2 degrader-35 (Compound 43) is a selective SMARCA2 PROTAC degrader with a DC50[2]. Pink: SMARCA2 ligand ; Blue: E3 ligase ligand; Black: linker

[3032998-97-0]

C39H38F3N9O5

769.77

OC1=C(F)C=CC=C1C2=NN=C3C(N(C[C@H](OC4=NC=C(CN5CCN(C6=CC=C7C(C(N([C@@H]8C(NC(CC8)=O)=O)C7)=O)=C6)CC5)C=C4)C9)[C@@]9(C(F)F)CN3)=C2

DNA/RNA Synthesis; PROTACs; SWI/SNF Complex

SMARCA2

Room temperature