PROTAC TRIB2 degrader-1 [CAS 3100306-42-8]

PROTAC TRIB2 degrader-1 (Compound 5k) is an effective TRIB2 degrader that selectively induces TRIB2 degradation through the CRBN-dependent ubiquitin-proteasome pathway. PROTAC TRIB2 degrader-1 can inhibit cell proliferation and induce cell apoptosis, and can be used in cancer research. (Target protein ligand (Pink) : HY-168275; linker (black) : HY-168276; E3 Ligase Ligand-Linker Conjugates: HY-168277; E3 ligase (Blue) : HY-W023573).

[3100306-42-8]

C45H45FN8O6

812.89

O=C(C1=NNC2=C1C=C(C3=CC=CN=C3F)C=C2)NC4=CC5=C(C=C4)CCN(C(CCCCCCCCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)C5

Apoptosis; PROTACs

Room temperature