ProTx-I [CAS 484598-35-8]

ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective CaV3.1 channel blocker with IC50 values of 0.2 μM and 31.8 μM for hCaV3.1 and hCaV3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na+ channels and inhibits KV 2.1 channels[1][2].

[484598-35-8]

C171H245N53O47S6

3987.49

O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(C)C)C(N[C@H]2C(C)C)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC(C)C)C(NCC(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC7=CNC=N7)C(NCC(N[C@H]8CC9=CNC%10=CC=CC=C9%10)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@H]3CSSC[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC%13=CC=CC=C%13)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)NC8=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N

Calcium Channel; Potassium Channel; Sodium Channel

T-type calcium channel

10 mM in DMSO

Room temperature