PSDalpha [CAS 2906869-08-5]

PSDalpha is an ERα degrader conjugating photosensitizer (PS), triphenylamine benzothiadiazole (TB) and 17β-estradiol via an acetylene bond. PSDalpha shows excellent anti-proliferation performance on MCF-7 cells. The maximum absorption wavelength of PSDalpha in the visible region is located at 465 nm[1].

[2906869-08-5]

C44H39N3O2S

673.86

C[C@@]12[C@](CC[C@]2(O)C#CC3=CC=C(C4=CC=C(C=C4)N(C5=CC=CC=C5)C6=CC=CC=C6)C7=NSN=C37)([H])[C@@]8([H])[C@@](CC1)([H])C9=CC=C(O)C=C9CC8

Estrogen Receptor/ERR

ERα

10 mM in DMSO

Room temperature