Pt (IV) -M13

Pt (IV) -M13 is a BBB-penetrable Platinum (IV) prodrug-perfluoroaryl macrocyclic peptide conjugate. Pt (IV) -M13 is cytotoxic to glioma stem cells and increases uptake of platinum in the brain. Pt (IV) -M13 can be used in the study of glioblastoma[1].

C120H190ClF8N30O28PtS2

2947.63

O=C(N[C@@H](C)C(NCC(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H]([C@H](CC)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CSC(C(F)=C2F)=C(F)C(F)=C2C3=C4F)=O)CCCCN)=O)CCCCN)=O)C)=O)CC(C)C)=O)C)=O)C)=O)CSC(C(F)=C3F)=C4F)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC([O-][Pt+4]([NH3])([Cl-])([NH3])([O-]C(NCCCC)=O)[C-])=O

Peptide-Drug Conjugates (PDCs)

Room temperature