PTPN2/1-IN-3

PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484. PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice[1].

C14H18FN3O4S

343.37

FC1=C(N2CC(NS2(=O)=O)=O)C(O)=CC3=C1CCN(CC)CC3

Phosphatase

99.89

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature