Purine riboside-5'-O-triphosphate (sodium) [CAS 35892-95-6]

Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine , acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM[1][2][3].

[35892-95-6]

C10H11N4Na4O13P3

580.09

O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)N2C3=NC=NC=C3N=C2

CaMK; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Room temperature