PWZ-029 [CAS 164025-33-6]

PWZ-029 is a selective inverse agonist for 5 GABAA receptors. PWZ-029 is a benzodiazepine site ligand. PWZ-029 shows a weak but significant partial agonistic effect at 1- and 3-containing receptors. PWZ-029 significantly increases retention session latency in mouse fibroblast cells. PWZ-029 can improve object recognition in normal and scopolamine-treated rat model[1][2].

[164025-33-6]

C14H14ClN3O2

291.73

O=C1N(CC2=C(N=CN2C3=CC=C(C=C13)Cl)COC)C

GABA Receptor

Room temperature