Pyridoxal isonicotinoyl hydrazone [CAS 737-86-0]

Pyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase (FECH) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia) [1][2][3][4][5][6].

[737-86-0]

C14H14N4O3

286.29

CC1=NC=C(C(/C=N/NC(C2=CC=NC=C2)=O)=C1O)CO

Biochemical Assay Reagents; Ferrochelatase

99.96

DMSO : 7 mg/mL (ultrasonic; heat to 60°C)

4°C (Powder, protect from light)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335