PZ-1129 [CAS 1919029-61-0]

PZ-1129 is a selective 5-HT7 receptor ligand with a Ki of 7 nM. PZ-1129 shows Ki values of 159 and 24 nM for 5-HT1A receptor and D2 receptor. PZ-1129 can inhibit the constitutive cAMP production mediated by the Gs signaling pathway (EC50 = 13.7 nM) . PZ-1129 can be used for the research of emotional disorders, such as depression and bipolar disorder[1].

[1919029-61-0]

C25H27FN2O3S

454.56

O=S(NC1CCN(CC1)CCOC2=C(C3=CC=CC=C3)C=CC=C2)(C4=CC=C(C=C4)F)=O

5-HT Receptor; Dopamine Receptor

5-HT1 Receptor;5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor; D2 Receptor

Room temperature