QC-01–175 [CAS 2267290-96-8]

QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 ; Black: linker NH2-PEG3 (HY-W007545) ; Blue: ligand for E3 ligase Pomalidomide (HY-10984) )[2].

[2267290-96-8]

C33H34N6O7

626.66

O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC4=CC5=C(C=C4)C(C=NC=C6)=C6N5

PROTACs; Tau Protein

10mM

99.94

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H315, H319, H320

H315, H319, H320