QI-18 [CAS 3093894-38-0]

QI-18 is a fibroblast activation protein (FAP) inhibitor with the IC50 of 0.50 nM, which is a 6.5-fold increase in potency over that of UAMC-1110. QI-18 can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors[1].

[3093894-38-0]

C31H27F2N7O7

647.59

OC(CNC([C@H](CC1=CC=C(C#N)C=C1)NC(COC2=CC=C(N=CC=C3C(NCC(N4CC(F)(F)C[C@H]4C#N)=O)=O)C3=C2)=O)=O)=O

FAP

Room temperature