QL-X-138 [CAS 1469988-63-3]

QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC50s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC50 of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies[1][2].

[1469988-63-3]

C25H19N5O2

421.45

C=CC(NC1=CC(N2C(C=CC3=C2C4=CC(C5=CNN=C5)=CC=C4N=C3)=O)=CC=C1C)=O

Btk; Dengue Virus; Flavivirus; MNK

99.77

DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature