QMT-CBT

QMT-CBT is a near-infrared aggregation-induced luminescent photon. After activation of caspase1 (Cas1), QMT-CBT undergoes a CBT-Cys click reaction to form a cyclic dimer QMT-Dimer (the first aggregate) and assembles into nanoparticles (the second aggregate), turning the AIE signal "on" to enhance imaging of Alzheimer's disease (AD) [1].

C94H89N19O12S4

1805.09

N#CC1=NC2=CC=C(NC([C@H](CC3=CN(CCOC4=CC=C(C5=CC=C(N(C6=CC=C(C7=CC=C(/C=C/C8=C/C(C(C=CC=C9)=C9N8CC)=C(C#N)/C#N)S7)C=C6)C%10=CC=CC=C%10)C=C5)C=C4)N=N3)NC([C@H](CSSC(C)(C)C)NC([C@H](CC(O)=O)NC([C@H](CC%11=CNC=N%11)NC([C@H](CCC(O)=O)NC([C@H](CC%12=CNC%13=CC=CC=C%12%13)NC(C)=O)=O)=O)=O)=O)=O)=O)C=C2S1

Biochemical Assay Reagents

Room temperature