R-03201195 [CAS 249936-55-8]

R-03201195 is an efficient and selective p38 MAP kinase inhibitor with an IC50 for p38α of 0.7 nM. R-03201195 has inhibitory activity against TNF-α in THP-1 cells and against IL-1β in human whole blood, with IC50 values of 0.25 and 0.57 nM respectively. R-03201195 can be used for inflammatory diseases such as rheumatoid arthritis[1].

[249936-55-8]

C19H18FN3O4

371.36

OC[C@H](O)COC1=CC=CC(C(C2=C(N)N(C3=CC=C(F)C=C3)N=C2)=O)=C1

Interleukin Related; p38 MAPK; TNF Receptor

IL-1; p38 MAPK

Room temperature