(R) -Benpyrine is the isomer of Benpyrine , and can be used as an experimental control. Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].
CAS Number
[2637243-08-2]
Molecular Formula
C16H16N6O
Molecular Weight
308.34
Smiles
O=C(N(CC1=CC=CC=C1)C2)C[C@H]2NC3=C4C(NC=N4)=NC=N3
Target
TNF Receptor
Concentration
10mM
Purity
99.17
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)