(R) -Brivanib alaninate-d4

(R) -Brivanib alaninate-d4 is the deuterium-labeled Brivanib (alaninate). Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ[1].

C22H20D4FN5O4

445.48

CC1=CC2=C(N1)C=CC(OC3=NC=NN4C3=C(C(OC[C@H](OC(C([2H])(C([2H])([2H])[2H])N)=O)C)=C4)C)=C2F

Isotope-Labeled Compounds

10 mM in DMSO

Room temperature