(R) -CMPD-39
(R) -CMPD-39
SKU:QM-0006914-01
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Product Details
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Description
(R) -CMPD-39 is the R enantiomer of CMPD-39. CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50 =~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients[1][2].
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Molecular Formula
C26H28FN3O4S
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Molecular Weight
497.58
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Smiles
CC(C)(C)NS(=O)(C1=CC=C(C=C1)NC([C@H](NC(C2=CC=C(C=C2)F)=O)CC3=CC=CC=C3)=O)=O
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Target
Deubiquitinase; Mitophagy
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Purity
99.78
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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(R) -CMPD-39
(R) -CMPD-39 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.