(R) -DRF053 [CAS 1056016-06-8]

(R) -DRF053 is a CDK inhibitor. (R) -DRF053 inhibits Cdk5 and promotes the formation of ductal precursor β cells. (R) -DRF053 inhibits Dil-ox-LDL uptake and CD36 gene expression induced by advanced glycation end products (AGEs) in U937 cells[1][2].

[1056016-06-8]

C23H27N7O

417.51

CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1

CDK

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501