(R) -MDL-101146 [CAS 163660-53-5]

(R) -MDL-101146 is the R-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis[1].

[163660-53-5]

C29H37F5N4O6

632.62

CC(C)[C@@H](C(N1[C@H](C(N[C@H](C(C)C)C(C(C(F)(F)F)(F)F)=O)=O)CCC1)=O)NC(C2=CC=C(C(N3CCOCC3)=O)C=C2)=O

Elastase

Room temperature