(R) - (+) -Mequitazine [CAS 147780-50-5]

(R) - (+) -Mequitazine is a histamine H1 receptor antagonist that mainly undergoes bio-transformation via human liver microsomes, resulting in hydroxylated and S-oxidized metabolites. (R) - (+) -Mequitazine competitively binds to the H1 receptors in gastrointestinal, vascular, and respiratory effect cells, thus blocking the endogenous activity of histamine. (R) - (+) -Mequitazine has an inhibitory effect on CYP3A-catalyzed midazolam 1’-hydroxylase. (R) - (+) -Mequitazine can be used in the study of various allergic diseases[1][2].

[147780-50-5]

C20H22N2S

322.47

C12=CC=CC=C1N(C[C@H]3CN4CCC3CC4)C5=C(C=CC=C5)S2

Histamine Receptor

Room temperature