(R) -MRT199665

(R) -MRT199665 is an isomer of MRT199665. MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370[1][2][3].

C28H31N5O2

469.58

O=C1C(C)(C)C2=CN=C(NC3=CC=CC(CN4CCCC4)=C3)N=C2N1[C@@H]5CCC6=C5C=CC=C6O

AMPK; Apoptosis; MARK; Salt-inducible Kinase (SIK)

98.7

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature