(R, R) -VRT-534 [CAS 926664-33-7]

(R, R) -VRT-534 is the (R, R) -enantiomer of VRT-534. VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment[1].

[926664-33-7]

C25H24ClN3O4S

497.99

O=C(C1(C2=CC=C3C(OCO3)=C2)CC1)NC(S4)=NC=C4[C@H](N(CC5)C[C@@H]5O)C(C=CC=C6)=C6Cl

Connexin; Gap Junction Protein

96.46

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature