(R, S, R) -ML334 [CAS 1432065-33-2]

(R, S, R) -ML334 is the isomer of ML334 , and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].

[1432065-33-2]

C26H26N2O5

446.5

O=C([C@H]1[C@@H](C(N2[C@@H](CN(C(C3=C4C=CC=C3)=O)C4=O)C5=C(C=CC=C5)CC2)=O)CCCC1)O

Drug Isomer

10mM

98.57

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501