(Rac) -GDC-2992 [CAS 2753650-84-7]

(Rac) -GDC-2992 (Compound 1) is a PROTAC androgen receptor degrader (DC50: 10 nM in VCaP cell). (Rac) -GDC-2992 blocks the process of androgen receptor transduction and also degrades the receptor itself. (Rac) -GDC-2992 can be used for prostate cancer research. Pink: AR ligand ; Blue: E3 ligase ligand (HY-W1003189) ; Black: linker (HY-169975).

[2753650-84-7]

C45H51ClN8O5

819.39

CC(C)([C@H](C1(C)C)NC(C2=CC=C(N3CCC(CC3)CN4CCN(C5=CC=C(C(N(C6C(NC(CC6)=O)=O)N=C7)=O)C7=C5)CC4)C=C2)=O)[C@H]1OC8=CC(Cl)=C(C=C8)C#N

Androgen Receptor; PROTACs

95

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C (Powder, protect from light, stored under nitrogen)

Blue Ice