(Rac) -Rivastigmine-d6 [CAS 194930-04-6]

(Rac) -Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB) . Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2].

[194930-04-6]

C14H16D6N2O2

256.37

O(C(N(CC)C)=O)C1=CC(C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])C)=CC=C1

Cholinesterase (ChE) ; Isotope-Labeled Compounds

10 mM in DMSO

Room temperature