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RAF-IN-1 [CAS 2695505-82-7]
RAF-IN-1 [CAS 2695505-82-7]
SKU:QM-0065761
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Product Details
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Description
RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1].
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CAS Number
[2695505-82-7]
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Molecular Formula
C26H22F3N3O4
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Molecular Weight
497.47
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Smiles
O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC4=C(C(NC5(CCOCC5)O4)=O)C=C3)=C2
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Target
Raf
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Isoform
B-Raf; C-Raf
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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RAF-IN-1 [CAS 2695505-82-7]
RAF-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.