Rafutrombopag (tautomerism) [CAS 2114365-78-3]
Rafutrombopag (tautomerism) [CAS 2114365-78-3]
SKU:QM-0140595-01
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Product Details
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Description
Rafutrombopag (tautomerism) (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease[1][2][3].
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CAS Number
[2114365-78-3]
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Molecular Formula
C25H22N4O5
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Molecular Weight
458.47
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Smiles
O=C(C1=CC=C(C2=C(O)C(/N=N/C3C(N(C4=CC=C5C(CCCC5)=C4)N=C3C)=O)=CC=C2)O1)O
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Target
Apoptosis; CDK; ERK; PI3K; STAT; Thrombopoietin Receptor
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Isoform
CDK4; CDK6; PI3K
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Purity
98.33
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Solubility
DMF : 6.25 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Rafutrombopag (tautomerism) [CAS 2114365-78-3]
Rafutrombopag (tautomerism) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.