Raloxifene 4'-glucuronide [CAS 182507-22-8]
Raloxifene 4'-glucuronide [CAS 182507-22-8]
SKU:QM-0062727
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Product Details
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Description
Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. [1][2]. Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[3].
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CAS Number
[182507-22-8]
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Molecular Formula
C34H35NO10S
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Molecular Weight
649.71
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Smiles
O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C(C3=C(C(C4=CC=C(OCCN5CCCCC5)C=C4)=O)C6=CC=C(O)C=C6S3)C=C2
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Target
Estrogen Receptor/ERR
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Purity
98.19
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Solubility
10 mM in DMSO
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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Raloxifene 4'-glucuronide [CAS 182507-22-8]
Raloxifene 4'-glucuronide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.