Raloxifene 6-glucuronide [CAS 174264-50-7]
Raloxifene 6-glucuronide [CAS 174264-50-7]
SKU:QM-0062726
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Product Details
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Description
Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[1][2][3].
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CAS Number
[174264-50-7]
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Molecular Formula
C34H35NO10S
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Molecular Weight
649.71
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Smiles
O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C(C(C(C3=CC=C(OCCN4CCCCC4)C=C3)=O)=C(C5=CC=C(O)C=C5)S6)C6=C2
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Target
Estrogen Receptor/ERR
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Raloxifene 6-glucuronide [CAS 174264-50-7]
Raloxifene 6-glucuronide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.