RDN2150 [CAS 2839429-51-3]

RDN2150 (Compound 25) is a ZAP-70 inhibitor (IC50: 14.6 nM) . RDN2150 covalently binds to the C346 residue of ZAP-70. RDN2150 inhibits the expression of CD25 and CD69, and inhibits CD4+ T cell activation. RDN2150 can be used for research of psoriasis[1].

[2839429-51-3]

C28H29ClN8O4

577.03

O=C(C1=C(N=C(N2C1=NC=C2)NCC3=CC(NC(C=C)=O)=C(C=C3)Cl)NC4=CC(OC)=C(C=C4)N5CCOCC5)N

Tyrosinase

10 mM in DMSO

Room temperature