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Regorafenib (mesylate) [CAS 835621-08-4]
Regorafenib (mesylate) [CAS 835621-08-4]
SKU:QM-0057309
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Product Details
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Description
Regorafenib (BAY 73-4506) mesylate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib mesylate shows very robust antitumor and antiangiogenic activity[1].
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CAS Number
[835621-08-4]
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Molecular Formula
C22H19ClF4N4O6S
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Molecular Weight
578.92
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Smiles
O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F.CS(O)(=O)=O
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Target
Autophagy; c-Kit; FGFR; PDGFR; Raf; RET; Tie; VEGFR
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Isoform
B-Raf; C-Raf; PDGFRβ; Tie2; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Regorafenib (mesylate) [CAS 835621-08-4]
Regorafenib (mesylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.