(rel) -AR234960 [CAS 1408311-94-3]

(rel) -AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. (rel) -AR234960 binds to the MAS receptor to activate the downstream ERK1/2 signaling pathway, inducing the expression of connective tissue growth factor (CTGF) and its downstream collagen subtype genes (such as COL1A1, COL3A1) . (rel) -AR234960 promotes collagen synthesis in cardiac fibroblasts through the MAS-ERK1/2-CTGF pathway and aggravates extracellular matrix remodeling. (rel) -AR234960's in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor. (rel) -AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure[1][2].

[1408311-94-3]

C27H30FN5O5S

555.62

O=S(N1C[C@@H](CN2CCN(C3=NC=CC=C3)CC2)[C@H](C4=CC=CC(F)=C4)C1)(C5=CC=C([N+]([O-])=O)C=C5OC)=O

ERK

98.95

DMSO : 25 mg/mL (ultrasonic; heat to 80°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature