RET-IN-1 [CAS 2222755-14-6]

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M), and RET (G810R), respectively [1].

[2222755-14-6]

C29H31N9O3

553.61

N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[C@H]7CNCCO7)=CN2N=C1

RET

10 mM in DMSO

Room temperature