RFRP-1 (human) (TFA)

RFRP-1 (human) TFA is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively) . Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.

C67H101N19O14S.xC2HF3O2

OC(C(F)(F)F)=O.NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H]2N(CCC2)C([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@@H](NC([C@H](CO)NC([C@H](CC3=CN=CN3)NC([C@H]4N(CCC4)C([C@@H](N)CCSC)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O

Neuropeptide Y Receptor

10 mM in DMSO

Room temperature