RFRP-3 (mouse)

RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR) . RFRP-3 (mouse) induces Apoptosis (increase of p53) . RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development[1].

C91H141N29O25S

2073.34

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Apoptosis; MDM-2/p53; Neuropeptide FF Receptor; PERK

Room temperature