RI-STAD-2

RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA) . RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer[1].

C109H181N25O35

2401.75

O=C([C@](NC1=O)(C)CCC/C=C/CCC[C@](C(N[C@H](C(N[C@H](C(N[C@H]1C)=O)CC2=CC=C(O)C=C2)=O)CCC(N)=O)=O)(C)NC([C@@H](NC(COCCOCCOCCN)=O)CC(C)C)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCC(O)=O)=O)[C@@H](C)O)=O)C)=O)CCC(O)=O)=O)CCCCN)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC(N)=O)=O)CC(O)=O)=O)C)=O)CC(C)C)=O)CCC(N)=O

PKA

10 mM in DMSO

Room temperature