Rilmenidine-d4 [CAS 85047-14-9]

Rilmenidine-d4 is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

[85047-14-9]

C10H12D4N2O

184.27

[2H]C1([2H])C([2H])(OC(NC(C2CC2)C3CC3)=N1)[2H]

Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor; Isotope-Labeled Compounds

10 mM in DMSO

Room temperature