Rineterkib [CAS 1715025-32-3]
Rineterkib [CAS 1715025-32-3]
SKU:QM-0138461-01
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Product Details
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Description
Rineterkib (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF[1][2].
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CAS Number
[1715025-32-3]
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Molecular Formula
C26H27BrF3N5O2
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Molecular Weight
578.42
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Smiles
O=C(N[C@@H](C1=CC(F)=CC(Br)=C1)CNC)C2=CC=C(C3=NC([C@@H]4C[C@H](F)[C@@H](O)CC4)=CN=C3N)C=C2F
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Target
ERK; Raf
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Isoform
ERK1; ERK2; Raf
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Purity
99.7
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Solubility
DMSO : 200 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Rineterkib [CAS 1715025-32-3]
Rineterkib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.