RIPK1-IN-11 [CAS 2173557-02-1]

RIPK1-IN-11 is a potent and orally active RIPK1 inhibitor (Kd=9.2 nM; IC50=67 nM) . RIPK1-IN-11 inhibits necroptosis in both human and mouse cells (EC50=17-30 nM) . Anti-inflammatory activity[1].

[2173557-02-1]

C23H24N4O4S

452.53

O=C(OC1CCOCC1)NC2=CC(C3=CC=C4N=C(NC(C5CC5)=O)SC4=C3)=CN=C2C

RIP kinase

RIPK1

10 mM in DMSO

Room temperature