RIPK1-IN-20 [CAS 3026543-19-8]

RIPK1-IN-20 (compound 13c) has a favorable RIPK1 kinase inhibition activity with an IC50 value of 59.8 nM. RIPK1-IN-20 blocks TNFα-induced necroptosis in both human and murine cells (EC50=1.06–4.58 nM) [1].

[3026543-19-8]

C28H26F3N5O4

553.53

O=C(N1CCC2=CC(C3=CN(CC4(COC4)C)C5=C3C(N)=NNC5=O)=CC=C21)CC6=CC(OC(F)(F)F)=CC=C6

Necroptosis; RIP kinase

10 mM in DMSO

Room temperature