RIPK1-IN-22

RIPK1-IN-13 (compound 28) is a selective inhibitor for receptor-interacting serine/threonine-protein kinase 1 (RIPK1), the inhibitory activity is measured by ADP-Glo Kinase Assay with a pKi of 7.66. RIPK1-IN-13 inhibits human leukaemia cells U937 with a pIC50 of 7.2[1].

C22H22N4O3S

422.5

CN(C1=CN=C(OC)C=C1CC[C@@H]2C(NC3=NC=C(CC4=CC=CC=C4)S3)=O)C2=O

RIP kinase

RIPK1

10 mM in DMSO

Room temperature