RIPK1-IN-23 [CAS 3031534-16-1]

RIPK1-IN-23 (compound 19) is a RIPK1 inhibitor with potent anti-necroptotic effects in HT-29 cells (EC50 of 1.7 nM) . RIPK1-IN-23 shows anti-inflammatory activities[1].

[3031534-16-1]

C27H22N6O3

478.5

CN1C([C@H](COC2=CC=C(C=C21)C3=CC=C(C=C3)C#N)NC(C4=NNC(CC5=CC=CC=C5)=N4)=O)=O

Necroptosis; RIP kinase

RIPK1

10 mM in DMSO

Room temperature