RIPK1-IN-30

RIPK1-IN-30 (compound 24) is a potent RIPK1 inhibitor with an IC50 of 2.01 μM. RIPK1-IN-30 exhibits protective effects in HT-29 cell model of TSZ-induced necroptosis with an EC50 of 6.77 μM[1].

C27H25FN2O4

460.5

FC1=CC=CC(CN2C(N(C3=CC=CC(C(CC4=CC(OCCO5)=C5C=C4)=O)=C3)CCC2)=O)=C1

RIP kinase

Room temperature